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Fallout 76 Boss Killer builds

Builds for single-target burst against the toughest enemies. Bring one when the boss health bar is the only number that matters.

Or start from scratch in the Character Build Planner and share your build.

Level 300+
s9
p13
e5
c3
i7
a10
l9
Low health human
Fallout 76 Endgame low health human commando build
Boss Killer
Endgame
Glass Cannon
Meta
Stealth
Published
byCaptnFnord¹⁶¹

Versatile low health build with weapon and armor options for damage, survival and tagging.

Level 300+
s8
p12
e7
c3
i8
a10
l8
Human bloodied power armor raid
Fallout 76 Human bloodied power armor raid build
Boss Killer
Endgame
Meta
Published
by@YEETitsDATBOI
Level 300+
s10
p10
e6
c4
i7
a14
l4
Heavy Energy Blood Sacrifice Tank
Fallout 76 Heavy Unlimited Vats build
Boss Killer
Endgame
Meta
Tank
Published
by@YEETitsDATBOI
Level 300+
s10
p9
e4
c3
i7
a11
l12
Mid lvl GMG Human
Fallout 76 build
Boss Killer
Meta
Tank
Published
byCaptnFnord¹⁶¹
Level 300+
s10
p8
e6
c4
i7
a8
l13
Heavy Gunner
Fallout 76 Big Guns build
Boss Killer
Endgame
Solo
Tank
Published / Updated
by@JustChasinIt
Create your own Fallout 76 build
Open the planner and publish it here
Level 300+
s10
p12
e6
c3
i5
a10
l10
Infinite Vats Minigun Low health
Fallout 76 build
Boss Killer×2
Tank×2
Close Range
Endgame
Published
byCaptnFnord¹⁶¹
Level 300+
s15
p7
e9
c10
i10
a1
l4
Ghoul Auto Axe build
Fallout 76 build
Boss Killer
Endgame
Melee
Tank
Published
byCaptnFnord¹⁶¹
Level 300+
s8
p14
e6
c2
i6
a10
l10
Enclave Plasma Flamer ENO6
Fallout 76 build
Boss Killer
Close Range
Published
by@poopman11

This is the best weapon I tests too down eno6 >1min

Level 14
s1
p3
e1
c1
i1
a7
l6
BARE BONES ENO6 SHEILD
Fallout 76 build
Boss Killer
Solo
Published
by@poopman11

I use the Chinese Stealth Armor. For solo this works great as long as your not up in his face it will be in Caution, if you do get spotted retreat behind the pillars and wait.

Level 300+
s15
p4
e10
c4
i10
a1
l3
Feral Ghoul Pain Train
Fallout 76 build
Boss Killer
Melee
Tank
Published / Updated
byCaptnFnord¹⁶¹

This build uses various hidden buffs to optimize Pain Train damage. especially regarding the weapon. To get the best results, you should bring down the durability of the Gatling Plasma to 1%. Note: firing into the air to get bullet storm stacks does NOT cost any durability, just ammo. Notes on the armor: Vulcan is the BIS for this build, but any PA that can have Tesla Bracers will do (no Excav/Ultracite!)

Level 300+
s10
p12
e4
c3
i7
a10
l10
Ghoul GMG/TC
Fallout 76 Ghoul Endgame Gauss Minigun Teslacannon Power Armor VATScrit build
Boss Killer
Endgame
Meta
Tank
Published
byCaptnFnord¹⁶¹
Level 300+
s10
p7
e4
c5
i10
a10
l10
Shotghoul Daily Driver
Fallout 76 Do it all Shotgun Ghoul build
AoE
Boss Killer
Close Range
Endgame
Meta
Published
byPsychoSquire

This build can raid, can daily, can solo most stuff. And the cold shoulder makes the snake a breeze. Still need to use reflective PA or some trick for ENO but explosive cold shoulder will even hold drill with ease. Shotguns have finally come into their own! Thanks Todd!!

Level 300+
s7
p7
e2
c11
i10
a10
l9
West Tek Monster
Fallout 76 Archer XP Build build
AoE
Boss Killer
Endgame
Fast Leveling
Stealth
Published
byPsychoSquire

Who needs Nuka Grenades with Hat Trick?! Solely an XP Build, you would have to change up the armor to use this as a daily driver. But, it is possible if that is done. Added Daily armor on beneath the XP set.

Level 300+
s10
p10
e6
c4
i7
a9
l10
PA Gauss Mini
Fallout 76 build
Boss Killer
Endgame
Published / Updated
bykatie s
Level 300+
s5
p7
e8
c1
i10
a15
l10
Assaultron Head 100k dmg
Fallout 76 Reverse onslaught battleloaders ghoul build
Boss Killer
Close Range
Glass Cannon
Team Player
Published / Updated
byOkibum Matt

Build your crit meter with your cryolator and allow reverse onslaught stacks to build up. Once you reach 30 stacks, switch to the assaultron head, bash until you proc battleloaders, VATS crit on the weak point of your enemy, and watch it melt away. Repeat process as needed.

Level 300+
s15
p10
e7
c3
i1
a10
l10
PA Raid Ghoul
Fallout 76 build
Boss Killer
Endgame
Long Range
Tank
Published / Updated
byCountHollow
Level 300+
s7
p12
e11
c2
i4
a5
l15
VATS Ghoul
Fallout 76 Ultimate AP Build build
Boss Killer
Long Range
Solo
Published / Updated
byFrxsty ⛄(RealYoutube_Frxsty)
Level 300+
s7
p10
e7
c4
i11
a10
l7
EN06 solo melter
Fallout 76 single shield cycle win build
Boss Killer
Endgame
Solo
Published / Updated
by@werxes
Level 300+
s10
p9
e10
c1
i6
a10
l10
Fusion splitter
Fallout 76 build
Boss Killer
Endgame
Meta
Tank
Published / Updated
by@werxes

Use pepper shaker on boss, ultracite laser on everything else. Tesla for tagging. All fusion cell-powered.

Level 300+
s10
p15
e4
c3
i4
a10
l10
End game Ghoul
Fallout 76 Stealth Commando build
Boss Killer
Endgame
Stealth
Published
byTrippingAcid
Level 300+
s10
p10
e7
c4
i5
a10
l10
1shotman
Fallout 76 justshotthegunbro build
Boss Killer
Endgame
Long Range
Team Player
Published
by@Kentic
Level 300+
s10
p7
e9
c3
i8
a9
l10
Ghoul Blood Sacrifice
Fallout 76 VATS Crit Heavy Weapons build
Boss Killer
Meta
Tank
Published / Updated
byOldBenTTV

This is mostly Tiller's build, with some minor tweaks to help manage carry weight.

Original: https://nukesdragons.com/@tiller/fallout-76/character/blood-sacri

Level 300+
s15
p9
e15
c3
i10
a3
l1
Ads gatplas Tank
Fallout 76 Full Health, Boss melting build
Boss Killer
Endgame
Tank
Published / Updated
by@Unity
Level 300+
s6
p10
e9
c1
i10
a10
l10
G ROS Bow v3.5
Fallout 76 Ghoul Bow w evade build
Boss Killer
Endgame
Exploration
Magic
Survival
Published / Updated
by@sec
Level 300+
s9
p15
e5
c6
i1
a10
l10
The Ghoul Raider
Fallout 76 Ghoul Commando build
Boss Killer
Endgame
Meta
Stealth
Team Player
Published
byExtasyyy™